CHEM 6860

Physical Chemistry of Proteins

Course Description

Course information provided by the 2025-2026 Catalog.

Physical studies of proteins, with emphasis on using single molecule methodologies and on studies of metalloproteins. Topics include: Physical/chemical concepts that include chemical structure and conformation of proteins, protein folding energy landscape, electron transfer theory, enzyme catalysis, chemical kinetics, and single-molecule kinetics. Experimental methodologies that include absorption and emission spectroscopy, fluorescence energy resonance transfer, confocal microscopy, total internal reflection fluorescence, single molecule spectroscopy, time correlated single photon counting, fluorescence correlation spectroscopy, atomic force microscopy, optical tweezers, magnetic tweezers, super-resolution imaging with optical microscopy. Protein structure and function that includes metalloprotein structure/function (bioinorganic chemistry), GFP and variants, protein labeling, motor proteins, protein-protein interactions, protein-DNA interactions, and live-cell imaging.

Prerequisites REF-FA25/Corequisites REF-FA25 CHEM 3880 or CHEM 3900, or equivalents. Corequisites: None.

Enrollment Priority REF-FA25 Enrollment preference given to: graduate students.

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