BIOMS 6110

Genome Maintenance Mechanisms

Course Description

Course information provided by the 2015-2016 Catalog.

This course focuses on the molecular mechanisms for preserving genomic integrity in eukaryotes. Topics discussed include sources of mutation, DNA repair, and cell cycle checkpoints. Also addressed is how genome maintenance impacts genome plasticity and evolution, as well as the relationship between genomic instability and disease, including cancer.

Prerequisites/Corequisites Prerequisite: BIOMG 2800, BIOMG 2801, as well as BIOMG 3300, BIOMG 3310, BIOMG 3330, or BIOMG 3350.

Outcomes

• Have an awareness of the various manifestations of genomic instability and how different genetic alterations can impact gene function.
• Understand how mutations arise, as well as how defects in genome maintenance mechanisms can result in genomic instability.
• Be familiar with how cells respond to and repair genome damage.
• Possess the ability to critically read primary scientific publications.

When Offered Fall.

Comments  Meets during first half of semester. 

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